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KMID : 0363620110320060018
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Journal of Korean Oriental Medicine
2011 Volume.32 No. 6 p.18 ~ p.29
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Anti-inflammatory Effect of Gyulpidaehwangbakcho-tang (Jupidahuangpoxiao-tang) in the Collagen-induced Arthritis Mouse Model
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Song Young-Il
Oh Min-Seok
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Abstract
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Objectives: To investigate anti-inflammatory and anti-arthritic effects of Gyulpidaehwangbakcho-tang (GDBT) extract in a murine model of rheumatoid arthritis.
Methods: The mice received 100㎍ of bovine type II collagen in Freund’s complete adjuvant by intradermal injection at the base of the tail on day 0 and a booster injection on day 21. The mice were orally administered with GDBT (200 or 50mg/kg dissolved in distilled water) daily from day 1 to day 21 after arthritis incidence, and monitored for disease incidence and the severity of arthritis up to day 21. In order to evaluate the effect of GDBT on disease progression, we examined pro-inflammatory cytokines including IL-β, IL-6, TNF-α, COX-2 and NOS-II.
Results: GDBT produced a significant and dose dependent inhibition of arthritis and inflammation during the entire duration of the study. This action was characterized by the decreased production of IL-β, IL-6, TNF-α, COX-2, and NOS-II in vivo.
Conclusion: We believe that the anti-arthritic activity of GDBT is due to its modulatory effect on the expression of pro-inflammatory cytokine in the synovium. Our results contribute towards validation of the traditional use of GDBT in the treatment of RA and other inflammatory joint disorders.
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KEYWORD
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Collagen induced arthritis, Gyulpidaehwangbakcho-tang, Citri pericarpium, Rhei radix et rhizome, Natrii sulfas, pro-inflammatory cytokines
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